Ongoing Projects

Here is a partial list of ongoing projects involving characterization of proteins responsible for key neuronal processes or disorders:

  • Steve Burden: role of signaling by MUSK in the neuromuscular synapse; protein clustering at the neuromuscular synapse
  • Moses Chao: neurotrophin signaling
  • Mitchell Chesler: Dynamics and effects of pH regulation in the brain
  • David Chiu: Neuroregeneration
  • Matthew Dalva (Thomas Jefferson University): Ephrin phosphoproteomics
  • Jeremy Dasen: Control of motor neuron identity and connectivity
  • Gordon Fishell: Development and integration of early born sst expressing interneurons
  • Robert Froemke: Role of oxytocin in maternal behavior
  • Wenbiao Gan: Experience-dependent plasticity of synaptic structure; in vivo studies of microglial functions in brain plasticity and pathology
  • Jorge Ghiso: Characterization of beta amyloid peptides
  • Barbara Hempstead (Weill Cornell): molecular mechanisms of neurotrophin signaling
  • Konstantin Ichtchenko: B anthracis toxin PTM characterization
  • Bryen Jordan (Albert Einstein CoM): Activity-dependent changes in PSD composition
  • Eric Kandel (Columbia University): mechanisms of synaptic plasticity
  • Eric Klann: eif2alpha phosphorylation in synaptic plasticity, memory, and brain disorders; translational control in synaptic plasticity and memory
  • Holger Knaut: Molecular regulation of trigeminal sensory ganglia by SDF1 in zebrafish
  • Cary Lai (Indiana University): neuregulin-ErbB signaling
  • Francis Lee (Weill Cornell) Functional analysis of variant bdnf (val66met)
  • Efrat Levy (NYU/NKI): Characterization of exosomes in Alzheimer’s disease
  • Paul Matthews (NYU/NKI): role of ApoE alleles in Alzheimer’s susceptibility; mechanism of increased risk for Alzheimer’s disease in diabetes
  • Simon Moller (St. John’s University): role of synuclein in Parkinson’s disease
  • Randy Nixon (NYU/NKI): Neurofilament phosphorylation
  • Niels Ringstad: molecular mechanisms of functioning of sensory neurons in C. elegans
  • Hyung Don Ryoo: retinal degeneration
  • Dimitris Placantonakis: Metabolomics and proteomics of gliomagenesis
  • Bernardo Rudy: Molecular components of a-type k+ channels; Development and function of 5ht3ar-expressing cortical gabaergic interneurons
  • Martin Sadowski: Physical interaction between apoE and Abeta
  • Jim Salzer: Phosphoproteomics of neuronal stimulation; Mechanisms of node of ranvier assembly
  • Einar M. Sigurdsson: Epitope-specific targeting of tau aggregates
  • Nicholas Stavropoulos: Mechanism of sleep in drosophila
  • Richard Tsien: Modulation of neurotransmission by Ca++ and activity
  • Clarissa L. Waites (Columbia SOM): Molecular pathway for synaptic vesicle maintenance and degradation
  • Ed Ziff: AMPAR-associated proteins and synaptic plasticity; PSD changes in aging mice