The goals of this course are to provide students with an introduction to protein structure and to demonstrate how knowledge of the three-dimensional structures of proteins affords an in-depth understanding of biological processes. A primer on structure determination by x-ray crystallography, electron microscopy and NMR spectroscopy will also be given.
4 credit hours.
Classes meet Mon., Wed. and Fri., 10:30 - 12:00.
Course starts on Mon., Sept. 12th.
Lectures (Mon. and Wed.) will be held in the Skirball 3rd floor
seminar room, and the discussion session (Fri.) will be held in the Skirball
3rd floor conference room.
Recommended text: "Introduction to Protein Structure" by Branden
and Tooze, available for purchase at the NYU Medical Bookstore and Amazon.com, and on reserve in the library.
Course director: Steve Hubbard - Skirball 3rd floor, Lab 4; 263-8938;
hubbard@saturn.med.nyu.edu
Course Schedule
Week 1 (9/12 - 9/16)
Principles of protein structure and folding
Steve Hubbard / Neville Kallenbach
Week 2 (9/19 - 9/23)
Introduction to x-ray crystallography and
electron microscopy
Steve Hubbard / Da-Neng Wang
Week 3 (9/26 - 9/30)
Protein-nucleic acid recognition
Joel Belasco
Week 4 (10/3 - 10/7)
Membrane proteins
Da-Neng Wang
Week 5 (10/10 - 10/14)
Enzyme structure and mechanism
Xiang-Peng Kong
Week 6 (10/17 - 10/21)
Chaperone-assisted protein folding and protein degradation
David Ron
Week 7 (10/24 - 10/28)
No class - Skirball retreat
Week 8 (10/31 - 11/4)
Ligand-receptor recognition
Moosa Mohammadi
Week 9 (11/7 - 11/11)
Protein-protein interactions in signal transduction
Steve Hubbard
Week 10 (11/14 - 11/18)
Molecular machines - myosin, kinesin, ion pumps
David Stokes
Week 11 (11/21 - 11/25) Mon. only (Thanksgiving week)
Mid-term exam
Week 12 (11/28 - 12/2)
Analysis of proteins by mass spectrometry
Tom Neubert
NMR methods for structure determination
Alexej Jerschow
Computational approaches in structural biology
Tim Cardozo
Week 13 (12/5- 12/9)
Mass spectrometry lab
Tom Neubert
Electron microscopy lab
David Stokes / Da-Neng Wang
X-ray crystallography lab
Steve Hubbard / Xiang-Peng Kong
Useful Links