The goals of this course are to introduce students to the molecular/structural mechanisms underlying biological processes, such as cellular signal transduction, membrane transport of ions/small molecules and muscle contraction, and to the techniques used in structural biology.
4 credit hours.
Classes meet Mon., Wed. and Fri., 10:30 - 12:00.
Lectures (Mon. and Wed.) will be held in the Skirball 3rd floor
seminar room, and the discussion session (Fri.) will be held in the Skirball
3rd floor conference room. *** Check for any
changes in class location on the appropriate week's web page. ***
Recommended text: "Introduction to Protein Structure" by Branden
and Tooze, available at the NYU Medical Bookstore and in the library.
Course director: Steve Hubbard - Skirball 3rd floor, Lab 4; 263-8938;
hubbard@saturn.med.nyu.edu
Course Schedule
Week 1 (9/15 - 9/19)
Principles of protein structure and folding
Steve Hubbard / Neville Kallenbach
Week 2 (9/22 - 9/26)
Introduction to x-ray crystallography
Steve Hubbard / XiangPeng Kong
Week 3 (9/29 - 10/3)
Introduction to electron microscopy
David Stokes / Da-Neng Wang
Week 4 (10/6 - 10/10)
Enzyme structure and mechanism
Xiangpeng Kong
Week 5 (10/13 - 10/17)
Molecular machines - myosin, kinesin, ion pumps
David Stokes
Week 6 (10/20 - 10/24)
Membrane proteins
Da-Neng Wang
Week 7 (10/27 - 10/31)
Protein-nucleic acid recognition
Joel Belasco
Week 8 (no class) (Skirball retreat)
Work on final papers
Week 9 (11/10 - 11/14)
Ligand-receptor recognition
Moosa Mohammadi
Week 10 (11/17 - 11/21)
Protein-protein interactions in signal transduction
Steve Hubbard
Week 11 (11/24 only) (Thanksgiving week)
Mid-term exam
Week 12 (12/1 - 12/5)
Analysis of proteins by mass spectrometry
Tom Neubert
NMR methods for structure determination
Alexej Jerschow
Computational approaches in structural biology
Tim Cardozo
Week 13 (12/8- 12/12)
X-ray crystallography lab
Steve Hubbard / Xiangpeng Kong
Mass spectrometry lab
Tom Neubert
Electron microscopy lab
David Stokes / Da-Neng Wang
Useful Links