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An effective immune response requires recruitment of the right cells to the right place at the right time. Our lab studies how lymphocyte trafficking is regulated. We are particularly interested in:
(1) What determines a lymphocyte's residence time in a given location?
(2) How are the gradients that direct immune cell migration established?
(3) How do the trafficking requirements of normal and leukemic T cells differ, and can these differences be targeted therapeutically?