Publications (Selected)

Structural basis for the interaction of the adaptor protein Grb14 with activated Ras. Qamra R, Hubbard SR. PLoS ONE 2013 Aug 13;8(8):e72473 [PubMed]

Insulin meets its receptor. Hubbard SR. Nature 493, 171-172 (2013) [PubMed]

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase. Hubbard SR. Cold Spring Harb Perspect Biol Mar 1;5(3). doi:pii: a008946. 10.1101/cshperspect.a008946 (2013) [PubMed]

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F. Bandaranayake RM, Ungureanu D, Shan Y, Shaw DE, Silvennoinen O, Hubbard SR. Nat Struct Mol Biol 19, 754-759 (2012) [PubMed] [4FVP] [4FVQ] [4FVR]

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. Wynn JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR. J Cell Biol 199, 317-329 (2012) [PubMed] [3TCA]

Mycobacterium tuberculosis prokaryotic ubiquitin-like protein (Pup) deconjugating enzyme Dop is an unusual aspartate amidase. Burns KE, McAllister F, Schwerdtfeger C, Mintseris J, Cerda-Maira F, Noens EE, Wilmanns M, Hubbard SR, Melandri F, Ovaa H, Gygi SP, Darwin KH. J Biol Chem 287, 37522-37529 (2012) [PubMed]

Agrin binds to the N-terminal region of Lrp4 and stimulates association between Lrp4 and the first Ig-like domain in MuSK. Zhang W, Coldefy AS, Hubbard SR, Burden SJ. J Biol Chem 286, 40624-40630 (2011) [PubMed]

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O. Nat Struct Mol Biol 18, 971-976 (2011) [PubMed]

Cytokine signaling exposed. Hubbard SR. Structure 19, 1-2 (2011) [PubMed]

Structure-guided identification of a laminin binding site on the laminin receptor precursor. Jamieson KV, Hubbard SR, Meruelo D. J Mol Biol 405, 24-32 (2011) [PubMed]

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Bergamin E, Hallock PT, Burden SJ, Hubbard SR. Mol Cell 38, 100-109 (2010) [PubMed] [3ML4]

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis. Cerda-Maira FA, Pearce MJ, Fuortes M, Bishai WR, Hubbard SR, Darwin KH. Mol Microbiol 77, 1123-1135 (2010) [PubMed]

Crystal structure of the Frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. Stiegler AL, Burden SJ, Hubbard SR. J Mol Biol 393, 1-9 (2009) [PubMed] [3HKL]

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Depetris RS, Wu J, Hubbard SR. Nat Struct Mol Biol 16, 833-839 (2009) [PubMed] [3HK0]

The juxtamembrane region of EGFR takes center stage. Hubbard SR. Cell 137, 1181-1183 (2009) [PubMed]

Structure and mechanism of the insulin receptor tyrosine kinase. Hubbard SR. Handbook of Cell Signaling, 2nd Ed (Bradshaw RA & Dennis EA, editors), Ch 45, 307-314 (2009)

Structures of serine/threonine and tyrosine kinases. Hubbard SR. Handbook of Cell Signaling, 2nd Ed (Bradshaw RA & Dennis EA, editors), Ch 58, 413-418 (2009)

Lrp4 is a receptor for Agrin and forms a complex with MuSK. Kim N, Stiegler AL, Cameron TO, Hallock PT, Gomez AM, Huang JH, Hubbard SR, Dustin ML, Burden SJ. Cell 135, 334-342 (2008) [PubMed]

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor. Wu J, Li W, Craddock BP, Foreman KW, Mulvihill MJ, Ji Q, Miller WT, Hubbard SR. EMBO J 27, 1985-1994 (2008) [PubMed] [3D94]

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Nat Struct Mol Biol 15, 251-258 (2008) [PubMed] [3BU3]

How IRE1 responds to ER stress. Ron D, Hubbard SR. Cell 132, 24-26 (2008) [PubMed]

Crystal structure of the human laminin receptor precursor. Jamieson KV, Wu J, Hubbard SR, Meruelo D. J Biol Chem 283, 3002-3005 (2008) [Pubmed] [3BCH]

Receptor tyrosine kinases: mechanisms of activation and signaling. Hubbard SR, Miller WT. Curr Opin Cell Biol 19, 117-123 (2007) [PubMed]

Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK. Stiegler AL, Burden SJ, Hubbard SR. J Mol Biol 364, 424-433 (2006) [PubMed] [2IEP]

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Bergamin E, Wu J, Hubbard SR. Structure 14, 1285-1292 (2006) [PubMed] [2HMH]

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. Hu J, Hubbard SR. J Mol Biol 361, 69-79 (2006) [PubMed] [2HDV] [2HDX]

EGF receptor activation: push comes to shove. Hubbard SR. Cell 125, 1029-1031 (2006) [PubMed]

Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Li S, Depetris RS, Barford D, Chernoff J, Hubbard SR. Structure 13, 1643-1651 (2005) [PubMed] [2B4S]

Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR. Mol Cell 20, 325-333 (2005) [PubMed] [2AUG] [2AUH]

EGF receptor inhibition: attacks on multiple fronts. Hubbard SR. Cancer Cell 7, 287-288 (2005) [PubMed]

Structural characterization of a novel Cbl phosphotyrosine-recognition motif in the APS family of adapter proteins. Hu J, Hubbard SR. J Biol Chem 280, 18943-18949 (2005) [PubMed] [1YVH]

Juxtamembrane autoinhibition in receptor tyrosine kinases. Hubbard SR. Nat Rev Cell Mol Biol 5, 464-470 (2004) [PubMed]

Oncogenic mutations in B-Raf: some losses yield gains. Hubbard SR. Cell 116, 764-766 (2004) [PubMed]

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR. Mol Cell 12, 1379-1389 (2003) [PubMed] [1RPY] [1RQQ]

Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor. Li S, Covino ND, Stein EG, Till JH, Hubbard SR. J Biol Chem 278, 26007-26014 (2003) [PubMed] [1P14]

Structural basis for dimerization of the Grb10 SH2 domain: implications for ligand specificity. Stein EG, Ghirlando R, Hubbard SR. J Biol Chem 278, 13257-13264 (2003) [PubMed] [1NRV]

Protein tyrosine kinases: autoregulation and small-molecule inhibition. Hubbard SR. Curr Opin Struct Biol 12, 735-741 (2002) [PubMed]

Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation. Till JH, Becerra M, Watty A, Lu Y, Ma Y, Neubert TA, Burden SJ, Hubbard SR. Structure 10, 1187-1196 (2002) [PubMed] [1LUF]

Autoinhibitory mechanisms in receptor tyrosine kinases. Hubbard SR. Front Biosci 7, d330-340 (2002) [PubMed]

Structure and autoregulation of the insulin-like growth factor-1 receptor kinase. Favelyukis S, Till JH, Hubbard SR, Miller WT. Nat Struct Biol 18, 1058-1063 (2001) [PubMed] [1K3A]

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors. Stein EG, Gustafson TA, Hubbard SR. FEBS Lett 493, 106-111 (2001) [PubMed]

Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism. Till JH, Ablooglu AJ, Frankel M, Bishop SM, Kohanski RA, Hubbard SR. J Biol Chem 276, 10049-10055 (2001) [PubMed] [1I44]

Mechanism-based design of a protein kinase inhibitor. Parang K, Till JH, Ablooglu AJ, Kohanski RA, Hubbard SR, Cole PA. Nat Struct Biol 8, 37-41 (2001) [PubMed] [1GAG]

Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate. Ablooglu AJ, Till JH, Kim K, Parang K, Cole PA, Hubbard SR, Kohanski RA. J Biol Chem 39, 30394-30398 (2000) [PubMed]

Protein tyrosine kinase structure and function. Hubbard SR, Till JH. Annu Rev Biochem 69, 373-398 (2000) [PubMed]

Structural basis for FGF receptor dimerization and activation. Plotnikov AN, Schlessinger J, Hubbard SR, Mohammadi M. Cell 98, 641-650 (1999) [PubMed] [1CVS]

Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta. Mandiyan V, Andreev J, Schessinger J, Hubbard SR. EMBO J 18, 6890-6898 (1999) [PubMed] [1DCQ]

Structural analysis of receptor tyrosine kinases. Hubbard SR. Prog Biophys Mol Biol 71, 343-358 (1999) [PubMed]

Src autoinhibition: let us count the ways. Hubbard SR. Nature Struct Biol 6, 711-714 (1999) [PubMed]

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. Mohammadi M, Froum S, Hamby JM, Schroeder MC, Panek RL, Lu GH, Eliseenkova AV, Green D, Schlessinger J, Hubbard SR. EMBO J 17, 5896-5904 (1998) [PubMed] [2FGI]

Autoregulatory mechanisms in protein-tyrosine kinases. Hubbard SR, Mohammadi M, Schlessinger J. J Biol Chem 273, 11987-11990 (1998) [PubMed]

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. Hubbard SR. EMBO J 16, 5572-5581 (1997) [PubMed] [1IR3]

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, Hubbard SR, Schlessinger J. Science 276, 955-960 (1997) [PubMed] [1AGW] [1FGI]

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Mohammadi M, Schlessinger J, Hubbard SR. Cell 86, 577-587 (1996) [PubMed] [1FGK]

Crystal structure of the tyrosine kinase domain of the human insulin receptor. Hubbard SR, Wei L, Ellis L, Hendrickson WA. Nature 372, 746-754 (1994) [PubMed] [1IRK]