Kishore Kuchibhotla Receives K99 Award

Thu, 11/12/2015 - 5:00am

Kishore Kuchibhotla received his undergraduate degrees in Physics and Brain/Cognitive Science from the Massachusetts Institute of Technology and a PhD in Biophysics from Harvard University. His doctoral thesis explored the structural and functional degeneration of cortical networks in Alzheimer's Disease using in vivo two-photon calcium imaging. He has been a postdoctoral fellow at the NYU School of Medicine for a little over 3 years in the laboratory of Robert Froemke and has been funded by a Charles H. Revson Senior Fellowship in Biomedical Sciences. Kishore's research in the Froemke Lab at NYU aims to address a question central to understanding neural circuits: how does the brain represent the same sound that has two different meanings when presented in different contexts? We encounter these situations every day; similar sounds or other sensations can trigger very different memories, action sequences or emotions based on the context within which they are presented. The inability to incorporate context into sensory perception, in contrast, is a hallmark of many neurological disorders including PTSD, autism and addiction. His research takes an integrative approach to address these questions by measuring network output with two-photon calcium imaging, recording synaptic inputs with whole-cell voltage-clamp recordings, and perturbing the activity of brain centers associated with attention and arousal using optogenetics. This is all done in awake and behaving mice allowing him to explore neural circuits while they are in action.