RNA Biology: Beyond the Central Dogma

RNA Biology: Beyond the Central Dogma

Monday, September 26, 2011

9:30 AM - 5:00 PM Farkas Auditorium
New York University School of Medicine,
540 First Ave., New York, NY

The 2011 Skirball Symposium is open to the public, with no registration fee.

Feel free to spread the word!

Little was known about the mechanism by which genes direct protein synthesis when, in the late 1950s, Francis Crick first articulated the Sequence Hypothesis and the Central Dogma of molecular biology: that sequence information can flow between DNA and RNA and from RNA to protein but not from protein back to nucleic acids. Indeed, the existence of an RNA intermediary (mRNA) carrying instructions for protein synthesis had not yet been confirmed, and the genetic code had not yet been deciphered. Since then, it has become clear that RNA plays a central role in biology, not only as a repository of sequence information but also as a target of regulation, a biochemical catalyst, and a regulator in its own right. The 2011 Skirball Symposium, “RNA Biology: Beyond the Central Dogma”, will bring together some of the world’s leading experts in RNA molecular biology to report recent breakthroughs in understanding the post-transcriptional control of gene expression and the regulatory impact of noncoding RNAs, as well as the importance of these processes for human disease.


9:30AM Introduction
Dr. Ruth Lehmann, Director -- The Skirball Institute, NYU School of Medicine
9:45AM Structural basis of decoding by the ribosome
Ochoa Lecturer
Venki Ramakrishnan
MRC Laboratory of Molecular Biology 
10:30AM Molecular mechanisms of RNA degradation
Elena Conti
Max Planck Institute for Biochemistry
11:15AM Coffee Break
11:35AM Mechanism and regulation of miRNA repression and miRNA turnover in mammalian cells
Witold Filipowicz
Friedrich Miescher Institute
12:20PM Genome Regulation by Long Noncoding RNAs
Howard Chang
Stanford University School of Medicine. HHMI
1:15PM Lunch
2:45PM The CRISPR/Cas Bacterial Immune System
Sylvain Moineau
Université Laval
3:30PM Maps of the RNA World
Robert Darnell
Rockefeller University, HHMI
4:15PM Translational Control of Cellular Senescence
Joel D. Richter
University of Massachusetts Medical School
5:00PM Closing - Dr. Ruth Lehmann, Skirball Institute

The 2011 Skirball Institute Twelfth Annual Symposium is organized by Ruth Lehmann, Joel Belasco, Dan Littman and Niels Ringstad

Direct all inquiries to Laura E. Rivera 212-263-3289