Destruction and Renewal

Destruction and Renewal

Destruction and Renewal in Biological Systems

April 30, 2004
9:30 AM
Farkas Auditorium
New York University School of Medicine

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Destruction and renewal form a leitmotif throughout human literature, art, politics, culture - and biology. Under the aegis of this distinctly expansive theme, this year’s Skirball Symposium provides a forum for examining degradation, repair, remodeling, and regeneration at the molecular, cellular, and organismal levels. The talks range widely over such remarkable processes as DNA repair, aging, cellular matrix remodeling, and limb regeneration.

Of special note is this year’s Severo Ochoa lecture, presented by Dr. Alfred Goldberg on the topic of protein turnover. The Ochoa lectureship was established by Drs. Bernard Levine and Joseph Schlessinger in 1998 to honor Severo Ochoa, Chairman of the Department of Pharmacology and then of Biochemistry at New York University School of Medicine. Dr. Ochoa shared the 1959 Nobel Prize in Physiology or Medicine with Arthur Kornberg of Stanford University for unraveling the mechanisms of the biological synthesis of ribonucleic acid and deoxyribonucleic acid.


9:30 AM


9:45 AM

The proteasome in protein turnover and antigen presentation to the immune system
Alfred Goldberg
Harvard Medical School

10:35 AM

Making ends meet: Double-strand break repair in human cells
Stephen West
Clare Hall Laboratories, Cancer Research UK

11:25 AM

Autophagy as a regulated pathway of cellular degradation
Daniel Klionsky
University of Michigan

12:30 PM


2:00 PM

The role of extracellular matrix remodeling in development
Zena Werb
University of California, San Francisco

2:50 PM

Mechansims of aging and neurodegeneration in C. elegans: Lessons from simple old animals
Monica Driscoll
Rutgers University

3:40 PM


4:00 PM

Axonal plasticity and regeneration in the adult CNS: Role of the Nogo receptor
Stephen Strittmatter
Yale University School of Medicine

4:50 PM

New limbs for old: Lessons from the newt
Jeremy Brockes
University College London