Jesus Torres-Vazquez

Assistant Professor, Skirball Institute of Biomolecular Medicine, Developmental Genetics. Department of Cell Biology

Ph.D., 2001, University of California, Irvine

Keywords:Vasculature, Angiogenesis, Endothelial, Morphogenesis, Zebrafish

 

 

Contact Information: 

Skirball Institute of Biomolecular Medicine
540 First Avenue 4th floor, Lab 15
New York, N.Y. 10016
Office Tel: (212) 263-0259
Lab Tel: (212) 263-0298
Fax: (212) 263-7760
E-mail: jesus.torres-vazquez@med.nyu.edu

Administrative Contact:

Dolly Chan
Tel: (212) 263-7595
Email: dolly.chan@med.nyu.edu


Mechanisms that Shape the Anatomical Patterning of the Vasculature in Zebrafish

We use the zebrafish as a model system to understand how vessels form with proper anatomy to perform their vital functions.

Areas of interest in the lab include:
1. The role of axon guidance cues and their receptors, like Semaphorins and Plexins, in shaping the vasculature
2. The genetic control of brain vascularization
3. How signaling pathways and/or physiological inputs crosstalk to modulate the formation of the vascular tree.

 

Selected Publications:

Zygmunt T, Trzaska S, Edelstein L, Walls J, Rajamani S, Gale N, Daroles L, Ramírez C, Ulrich F, Torres-Vázquez J. (2012). In parallel interconnectivity of the dorsal longitudinal anastomotic vessels requires both VEGF signaling and circulatory flow. J Cell Sci. Aug 16. PMID: 22899709

Tomasz Zygmunt; Carl M Gay; Jordan Blondelle; Manvendra K Singh, Kathleen M Flaherty; Paula C Means; Lukas Herwig; Alice Krudewig; Heinz-Georg Belting; Markus Affolter; Jonathan A Epstein and Jesús Torres-Vázquez. (2011). Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1. Developmental Cell 21 (2), 301-14. PMID: 21802375

Florian Ulrich, Leung-Hang Ma, Robert G. Baker and Jesús Torres-Vázquez. (2011). Neurovascular development in the embryonic zebrafish hindbrain. Developmental Biology 357 (1), 134-151. PMID: 21745463

Carl M. Gay*, Tomasz Zygmunt* and Jesús Torres-Vázquez. (2010). Diverse functions for the Semaphorin receptor PlexinD1 in development and disease. Developmental Biology 349 (1), 1-19. PMID: 20880496

Jesús Torres-Vázquez, Aaron D. Gitler, Sherry D. Fraser, Jason A. Berk, Van N. Pham, Mark C. Fishman, Sarah Childs, Jonathan A. Epstein and Brant M. Weinstein. (2004). Semaphorin-Plexin signaling guides patterning of the developing vasculature. Developmental Cell 7(1), 117-123. PMID: 15239959

Click here to see all publications in PubMed