Jessica E. Treisman

Professor, Skirball Institute of Biomolecular Medicine, Developmental Genetics. Department of Cell Biology. Coord Developmental Genetics Program

Ph.D., 1991 Rockefeller University

Lab Website:

Keywords: Drosophila, Eye, Signaling, Synaptogenesis


Contact Information: 

Skirball Institute of Biomolecular Medicine
540 First Avenue 4th floor, Lab 9
New York, N.Y. 10016
Office Tel: (212) 263-1031
Lab Tel: (212) 263-1032
Fax: (212) 263-7760

Administrative Contact:

Theresa Walton
Tel: (212) 263-7595

Cell Communication in Drosophila Visual System Development

Cells must communicate with each other during development to determine their positions within the organism and to take on the appropriate fates. The Drosophila visual system is a useful model system in which to examine how this communication occurs. Mutations that disrupt the ordered pattern of photoreceptor differentiation are easy to identify and have led us to uncover some unexpected signaling mechanisms. We currently work on lipid modifications of secreted signaling proteins, trafficking and endocytosis of receptors and ligands, and the regulation of protein stability. We are also interested in chromatin-based mechanisms in the transcriptional and post-transcriptional control of gene expression. In addition to cell fate choices, we study how neurons interact with each other to choose the correct synaptic partners. We use both the adult color-sensitive photoreceptors and the larval motor neurons to investigate the molecular mechanisms that allow synapses to form in the correct locations and to change over time.

Selected Publications:

K. Legent, J. Steinhauer, M. Richard, and J.E. Treisman. 2012. A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1 alpha as an essential negative regulator of Wingless signaling. Genetics 190, 601-616. PMID: 22095083

S. Astigarraga, K. Hofmeyer, R. Farajian, and J.E. Treisman. 2010. Three Drosophila Liprins interact to control synapse formation. J. Neurosci. 30,15358-15368. PMID: 21084592

J.-Y. Roignant and J.E. Treisman. 2010. Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene. Cell 143, 238-250. PMID:20946982

J.-Y. Roignant, K. Legent, F. Janody, and J.E. Treisman. 2010. The transcriptional cofactor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. Development 137, 273-281. PMID: 20040493

K. Hofmeyer and J.E. Treisman. 2009. The receptor protein tyrosine phosphatase LAR promotes photorecep tor axon targeting by a phosphatase-independent signaling mechanism. Proc. Natl. Acad. Sci. USA 106, 19399-19404. PMID: 19889974

Click here to see all publications in PubMed