E. Jane Albert Hubbard

Associate Professor, Skirball Institute of Biomolecular Medicine, Developmental Genetics. Department of Pathology. Coord Developmental Genetics Program

Ph.D., 1993 Columbia University

Keywords: C. elegans, Stem Cells, Germ Line, Signal Transduction

 

 

Contact Information: 

Skirball Institute of Biomolecular Medicine
540 First Avenue 4th floor, Lab 7
New York, N.Y. 10016
Office Tel: (212) 263-7154
Lab Tel: (212) 263-7533
Fax: (212) 263-7760
E-mail: jane.hubbard@med.nyu.edu

Administrative Contact:

Theresa Walton
Tel: (212) 263-7595
Email: theresa.walton@med.nyu.edu


Developmental Genetics of Germline Proliferation in C. elegans

During the development and maintenance of tissues and organs, cells must decide whether, when, where and how much to proliferate. Improper regulation of cell proliferation or differentiation can lead to developmental defects and cancer. We focus on the control of proliferation and differentiation germline progenitor pool using C. elegans as a model. Similar control mechanisms are shared in all organisms. We are particularly interested in how signaling pathways influence germline proliferation/differentiation during the co-development of the germline and somatic gonad and establishment of the germ line stem cell pool. Our recent studies implicate the TOR, insulin receptor, and TGFß signaling pathways in these processes. We are investigating how metabolic and sensory cues interact through these signaling pathways, and how they network with direct niche-stem cell signaling to regulate germline development.

Selected Publications:

M. McGovern, R. Voutev, J. Maciejowski, A. Corsi, and E.J.A. Hubbard. A “latent niche” mechanism for tumor initiation. Proc. Natl. Acad. Sci. USA 2009;106:11617-22. PMID: 19564624

D. Michaelson, D.Z. Korta, Y. Capua, and E.J.A. Hubbard. Insulin signaling promotes germline proliferation in C. elegans. Development 2010; 137:671-80. PMID: 20110332

Y. Setty, D. Dalfó, D.Z. Korta, E.J.A. Hubbard*, and H. Kugler.* A model of stem cell population dynamics: in silico analysis and in vivo validation. Development 2012; 139:47-56. PMID: 22147952

D.Z. Korta, S. Tuck, and E.J.A. Hubbard. S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells. Development 2012; 139:859-870. PMID: 22278922

D. Dalfó, D. Michaelson, and E.J.A. Hubbard. Sensory Regulation of the C. elegans Germline through TGF-b-Dependent Signaling in the Niche. Current Biology 2012; 22:712-719. PMID: 22483938

Click here to see all publications in PubMed