Thesis projects in the structural and mechanistic characterization of membrane transporters and channels are available for motivated Ph.D. candidates. Our laboratory is specifically interested in transporter proteins involved in neurotransmission, nutrient uptake and bacterial antibiotic resistance. Students are encouraged to contribute to the formulation of their thesis project. Once an interesting transport paradigm is chosen, we will use a combination of X-ray crystallography, biochemical and biophysical techniques to address its key mechanistic questions.
Our lab has a strong track record in training graduate students as demonstrated by the 100% success rate for each of our Ph.D. students in crystallizing and solving the structure of a novel membrane protein and publishing their work in top research journals. While structure determination of membrane proteins is notoriously challenging, the friendly and interactive environment of the lab provides the best support for approaching this difficult task.