Wenbiao Gan

Professor, Skirball Institute of Biomolecular Medicine, Molecular Neurobiology. Department of Physiology and Neuroscience

Ph.D., 1995 Columbia University

Gan Lab
Synapses, Dendritic Spines, Cortex, Learning, Imaging

Contact Information

Skirball Institute of Biomolecular Medicine
540 First Avenue 5th floor, Lab 4
New York, N.Y. 10016
Office Tel: (212) 263-2585
Lab Tel: (212) 263-2586
Fax: (212) 263-8214
E-mail: wenbiao.gan@med.nyu.edu

Admin Contact

Susan Ha
Tel: (212) 263-6354
Email: susan.ha2@med.nyu.edu

Mechanisms of Synaptic Plasticity and Stability

Synaptic PlasticityWe are interested in understanding how learning experiences and sleep lead to changes of synaptic connectivity in the brain. We also study the role of microglia in synapse development and pathology in mouse models of Alzheimer’s disease.





Selected Publications: 
  • Yang, G., Pan, F., Lin, A, Gan, W-B. (2009) Stably maintained dendritic spines are associated with lifelong memories. Nature. 462:920-4. PMID: 19946265.
  • Lai CS, Franke TF, Gan W-B. (2012) Opposite effects of fear conditioning and extinction on dendritic spine remodelling. Nature. 483:87-91. PMID:22343895.
  • Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR III, Lafaille JJ, Hempstead BL, Littman DR, Gan W-B (2013) Microglia promote learning-dependent synapse formation through BDNF. Cell 155:1596-609. PMID: 24360280
  • Yang G, Lai CS, Cichon J, Ma L, Li W, Gan W-B. (2014) Sleep promotes branch-specific formation of dendritic spines after learning. Science. 344(6188):1173-8. PMID: 24904169.
  • Cichon J, Gan W-B. (2015) Branch-specific dendritic Ca2+ spikes cause persistent synaptic plasticity.  Nature 520:180-5. PMID: 25822789.

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