Jessica E. Treisman

Professor, Skirball Institute of Biomolecular Medicine, Developmental Genetics. Department of Cell Biology. Coord Developmental Genetics Program

Ph.D., 1991 Rockefeller University

Treisman Lab
Drosophila, Eye, Signaling, Synaptogenesis

Contact Information

Skirball Institute of Biomolecular Medicine
540 First Avenue 4th floor, Lab 9
New York, N.Y. 10016
Office Tel: (212) 263-1031
Lab Tel: (212) 263-1032
Fax: (212) 263-7760

Admin Contact

Eileen Cordero
Tel: (646) 501-0679

Cell Communication in Drosophila Visual System Development

Cells must communicate with each other during development to determine their positions within the organism and to take on the appropriate fates. The Drosophila visual system is a useful model system in which to examine how this communication occurs. Mutations that disrupt the ordered pattern of photoreceptor differentiation are easy to identify and have led us to uncover novel signaling mechanisms. We currently work on modifications that regulate protein stability and the distribution of secreted proteins. We are also interested in the transcriptional network that specifies the photoreceptor cell fate. In addition, we study how neurons choose the correct synaptic partners as they assemble into neural circuits. We use both the adult visual system and the larval motor neurons to investigate the molecular mechanisms that allow synapses to form in the correct locations and to change over time.

Selected Publications: 
  • K. Legent, H.H. Liu and J.E. Treisman. 2015. Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation. Development 142, 1480-1491. PMID: 25790850
  • C. Malone, C. Mestdagh, J. Akhtar, N. Kreim, P. Deinhard, R. Sachidanandam, J. Treisman and J.-Y. Roignant. 2014. The exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript. Genes Dev. 28, 1786-1799. PMID: 25104425
  • J. Steinhauer, H.H. Liu, E. Miller, and J.E. Treisman. 2013. Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues. J. Cell Sci. 126, 4469-4478. PMID: 23902690
  • K. Legent, J. Steinhauer, M. Richard, and J.E. Treisman. 2012. A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1 alpha as an essential negative regulator of Wingless signaling. Genetics 190, 601-616. PMID: 22095083
  • S. Astigarraga, K. Hofmeyer, R. Farajian, and J.E. Treisman. 2010. Three Drosophila Liprins interact to control synapse formation. J. Neurosci. 30,15358-15368. PMID: 21084592

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