E. Jane Albert Hubbard

Professor, Skirball Institute of Biomolecular Medicine, Developmental Genetics. Departments of Cell Biology and Pathology. Coord Developmental Genetics Program

Ph.D., 1993 Columbia University

J Hubbard Lab
Signal Transduction, C. elegans, Stem Cells, Germ Line

Contact Information

Skirball Institute of Biomolecular Medicine
540 First Avenue 4th floor, Lab 7
New York, N.Y. 10016
Office Tel: (212) 263-7154
Lab Tel: (212) 263-7533
E-mail: jane.hubbard@med.nyu.edu

Admin Contact

Eileen Cordero
Tel: (646) 501-0679
Email: eileen.cordero@med.nyu.edu

Developmental Genetics of Germline Proliferation in C. elegans

Germline Proliferation in C. elegansDuring the development and maintenance of tissues and organs, cells must decide whether, when, where and how fast to proliferate. Improper regulation of cell proliferation or differentiation can lead to developmental defects and cancer. We use the germline progenitor pool in C. elegans as a model. Similar control mechanisms are shared in all organisms. Our recent studies implicate the TOR, insulin receptor, and TGFß signaling pathways in these processes. We are investigating how physiological, nutritional and sensory cues interact through these signaling pathways, and how they network with niche-stem cell signaling to regulate germline development and germline stem cell maintenance.

Selected Publications: 
  • M. McGovern, R. Voutev, J. Maciejowski, A. Corsi, and E.J.A. Hubbard. A “latent niche” mechanism for tumor initiation. Proc. Natl. Acad. Sci. USA 2009;106:11617-22. PMID: 19564624
  • D. Michaelson, D.Z. Korta, Y. Capua, and E.J.A. Hubbard. Insulin signaling promotes germline proliferation in C. elegans. Development 2010; 137:671-80. PMID: 20110332
  • D.Z. Korta, S. Tuck, and E.J.A. Hubbard. S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells. Development 2012; 139:859-870. PMID: 22278922
  • D. Dalfó, D. Michaelson, and E.J.A. Hubbard. Sensory Regulation of the C. elegans Germline through TGF-b-Dependent Signaling in the Niche. Current Biology 2012; 22:712-719. PMID: 22483938
  • Z. Qin and E.J.A. Hubbard. Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells. Nat Commun. 2015; 6:7107. doi: 10.1038/ncomms8107. PMID:25960195

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